Mehmet Sayar Curriculum Vitae Personal Information { { { { Date of birth: March 20, 1973 Place of birth: Eskişehir, Turkey Country of Citizenship: Republic of Turkey Languages: Turkish (native), English (fluent), German (beginner) Education and Academic Career 2005–present Assistant Professor, Department of Mechanical Engineering and Department of Chemical & Biological Engineering, Koç University, Istanbul, Turkey. 2003–2005 Postdoctoral Research Associate, Max-Planck Institute for Polymer Research, Mainz, Germany. Theory Group of Prof. Dr. Kurt Kremer, Project Leader: Dr. Christian Holm 1999–2003 Ph.D., Department of Materials Science and Engineering, Northwestern University, USA. Thesis Advisor: Prof. Dr. Samuel I. Stupp 1997–1999 M.S., Department of Materials Science and Engineering, University of Illinois, Urbana/Champaign, USA. Thesis Advisor: Prof. Dr. Samuel I. Stupp 1996–1997 Research and Teaching Assistant, Polymer Research Center and Department of Civil Engineering, Boğaziçi University, Istanbul, Turkey.. Research Advisor: Prof. Dr. Ali R. Atılgan 1994–1995 Undergraduate Research Assistant, Department of Civil Engineering, Boğaziçi University, İstanbul, Turkey. Research Advisor: Prof. Dr. Ali R. Atılgan 1992–1996 B.S., Department of Civil Engineering, Boğaziçi University, Istanbul, Turkey. Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 1/8 Awards and Fellowships 2012 TÜBA GEBİP Young Scientist Award. 2004 Marie Curie Intra European Fellowship. Postdoctoral Research 2001 Nanoscale Science and Engineering Center Graduate Fellow. Northwestern University 1997 Fulbright Scholarship. M. Sc. at University of Illinois Urbana Champaign 1996 Honor student. Boğaziçi University, Faculty of Engineering 1992 Boğaziçi University Alumni Association Award. Scholarship granted to those students who rank first when entering their departments. 1991 Hacı Ömer Sabancı Foundation Award. Scholarship granted to those students who rank in the top 1% in the national university entrance examination Projects Submitted TÜBİTAK 1001 Project Proposal , Title: “Aggregation of Polyglutamine Tracts Sep. 2015 Driven by httN T α-helices”, Position: Principle Investigator. Budget: 340760 TL 2015-2018 TÜBİTAK 1001 Project (114F348), Title: “Dynamical behavior of helical biomolecules and the influence of geometrical entanglement on scaling properties”, Position: Investigator. Budget: 367002 TL 2013-2016 TÜBİTAK-DFG Joint Research Project (212T184), Title: “Multiscale simulation of environment-induced conformational transitions in peptides: folding, partitioning and aggregation”, Position: Principle Investigator. Budget: 258452 TL 2012–2014 TÜBİTAK 1001 Project (112T496), Title: “Formation. Structure and Stability of Nanofibers and Networks Formed by Amphiphilic Peptides”, Position: Principle Investigator. Budget: 128120 TL 2011–2012 Max-Planck Society Partner Group Grant, Scientific Collaboration with MaxPlanck Institute for Polymer Research, Position: Principle Investigator. Extended for one more year after the successfull completion of the second phase of the project. Budget: 20000 Euro 2009–2012 TÜBİTAK 1001 Project (108T553), Title: “A coarse-grained model of DNA and the investigation of the equilibrium plasmid structures as a function of temperature”, Position: Principle Investigator. Budget: 121780 TL 2009–2011 Max-Planck Society Partner Group Grant, Scientific Collaboration with MaxPlanck Institute for Polymer Research, Position: Principle Investigator. Extended for two more year after the successfull completion of the second phase of the project. Budget: 40000 Euro Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 2/8 2007–2009 TÜBİTAK National Young Scientist Career Development Grant, Title: “Computational Analysis of Self-Organization of Like-Charged Organic Molecules into Nanoscale Structures”, Position: Principle Investigator. Budget: 87500 TL 2006–2009 Max-Planck Society Partner Group Grant, Scientific Collaboration with MaxPlanck Institute for Polymer Research, Position: Investigator. 60000 Euro Graduate Students 2005-2007 Özge (Engin) Şensoy, M.S. degree in CMSE, co-advised with Prof. Burak Erman, continued her education as a Ph.D. student in my group. 2007-2011 Dr. Özge (Engin) Şensoy, Ph.D. degree in CMSE, worked as a postdoctoral research associate at Weill Cornell Medical College. Currently a full time faculty member as Assistant Professor at Medipol University, Istanbul, Turkey. 2009-2014 Dr. Cahit Dalgıçdir, Ph.D. degree in CMSE, currently a postdoctoral research associate at Konstanz University, Germany. 2011-2013 Murat Öztürk, M.S. degree in CMSE, co-advised with Asst. Prof. Kabakçıoğlu, Currently a PhD. candidate at Indiana University, USA. Alkan 2012-2014 Deniz Aydın, M.S. degree in CHBI, co-advised with Prof. Burak Erman, currently a PhD. candidate at EPFL, Switzerland. 2012-2015 Ayşegül Turupçu, M.S. degree in CHBI, co-advised with Prof. Burak Erman, currently a PhD. candidate at University of Natural Resources and Life Sciences Vienna, Austria. 2013-2015 Farhad Ramezanghorbani, M.S. degree in CMSE, currently a PhD. candidate at University of Florida, USA. 2010-to date Beytullah Özgür, Ph.D candidate in CMSE. 2015-to date Doğancan Özturan, Ph.D. candidate in BMSE. Citations Google Scholar Citation Indices Citations h-index i10-index Web of Knowledge All 372 13 15 Since 2010 192 8 8 Sum of Times Cited Sum of Times Cited without self-citations Citing Articles Citing Articles without self-citations Average Citations per Item h-index Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 287 277 263 256 11.48 11 3/8 Manuscripts Submitted and in Preparation [1] Aydin, D., Gul, A., Erman, B., & Sayar, M. A comparative molecular dynamics study of HLA-B*51 and HLA-B*52: Implications for the pathogenic role of HLA-B*51 in Behçet’s Disease. (Submitted). [2] Dalgicdir, C. & Sayar, M. Conformation and Aggregation of LK Peptide in Bulk Water and at the Air/Water Interface. J. Phys. Chem. B (Submitted). [3] Beytullah, O. & Sayar, M. Network Formation in ABA Triblock Peptides: A Coarse Grained MD Analysis. (In preparation). [4] Beytullah, O. & Sayar, M. Aggregation of Polyglutamine Tracts Driven by httNT alpha-helices. (In preparation). [5] Dalgicdir, C. & Sayar, M. Application of Iterative Boltzmann Method to Phase Separating Binary Mixtures. (In preparation). [6] Dalgicdir, C., Globisch, C., Peter, C., & Sayar, M. A Transferrable Coarse Grained Model For EALA Peptide. (In preparation). [7] Ozgur, B. & Sayar, M. Coarse Grained Modeling of ABA Triblock Peptides. (In preparation). [8] Ozturk, M., Sayar, M., & Kabakcioglu, A. Supercoiling Behavior of DNA under Torsional Stress. (In preparation). [9] Ramezanghorbani, F., Dalgicdir, C., & Sayar, M. How to represent environment driven coconformation transitions in peptides? (In preparation). [10] Turupcu, A., Erman, B., & Sayar, M. Molecular Dynamics Simulation of IL-1 Receptor Superfamily Members. (In preparation). Publications [1] Dalgicdir, C., Globisch, C., Peter, C., & Sayar, M. Tipping the Scale from Disorder to Alpha-helix: Folding of Amphiphilic Peptides in the Presence of Macroscopic and Molecular Interfaces. PLoS Comput Biol 11, e1004328 (2015). [2] Bakota, E. L., Sensoy, O., Ozgur, B., Sayar, M., & Hartgerink, J. D. Self-Assembling Multidomain Peptide Fibers with Aromatic Cores. Biomacromolecules 14, 1370–1378 (2013). [3] Dalgicdir, C., Sensoy, O., Peter, C., & Sayar, M. A transferable coarse-grained model for diphenylalanine: How to represent an environment driven conformational transition. J. Chem. Phys. 139, 234115 (2013). [4] Engin, O. & Sayar, M. Adsorption, Folding and Packing of an Amphiphilic Peptide at the Air/Water Interface. J. Phys. Chem. B 116 (7), 2198–2207 (2012). [5] Engin, O., Villa, A., Peter, C., & Sayar, M. A Challenge for Peptide Coarse Graining: Transferability of Fragment-Based Model. Macromol. Theory Simul. 20, 451–465 (2011). [6] Engin, O., Villa, A., Sayar, M., & Hess, B. Driving Forces for Adsorption of Amphiphilic Peptides to Air-Water Interface. J. Phys. Chem. B 114, 11093–11101 (2010). Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 4/8 [7] Sayar, M. & Holm, C. Equilibrium Polyelectrolyte Bundles with Different Multivalent Counterion Concentrations. Phys. Rev. E 82, 031901 (2010). [8] Sayar, M., Bavsaroglu, B., & Kabakcioglu, A. Twist-writhe partitioning in a coarsegrained DNA minicircle model. Phys. Rev. E 81, 04916 (2010). [9] Engin, O., Sayar, M., & Erman, B. The introduction of hydrogen bond and hydrophobicity effects into the rotational isomeric states model for conformational analysis of unfolded peptides. Phys. Biol. 6, 016001 (2009). [10] Engin, O. & Sayar, M. In Hansman, U. H. E., Meinke, J., Mohanty, S., Nadler, W., & Zimmermann, O. (eds.), From Computational Biophysics to Systems Biology (CBSB08), Proceedings of the NIC Workshop 2008, vol. 40 (2008). [11] Emanuel, M., Mohrbach, H., Sayar, M., Schiessel, H., & Kulic, I. M. Buckling of stiff polymers: Influence of thermal fluctuations. Phys. Rev. E 76, 1703–1707 (2007). [12] Hess, B., Sayar, M., & Holm, C. Stability of Hydrophobically Modified Poly(pphenylene)sulfonate Bundles as Observed by Molecular Dynamics Simulation. Macromolecules 40, 1703 (2007). [13] Sayar, M. & Holm, C. Finite Size Polyelectrolyte Bundles at Thermodynamic Equilibrium. Europhys. Lett. 77, 16001 (2007). [14] Sayar, M. & Stupp, S. I. Assembly of 1D Supramolecular Objects: From Monomers to Networks. Pyhs. Rev. E 72, 011803 (2005). [15] Limbach, H. J., Sayar, M., & Holm, C. Polyelectrolyte Bundles. J. Phys. Condens. Matter 16, 2135–2144 (2004). [16] Lecommandoux, S., Klok, H. A., Sayar, M., & Stupp, S. I. Synthesis and selforganization of rod-dendron and dendron-rod-dendron molecules. J. Phys. A, Poly. Chem. 41, 3501–3518 (2003). [17] Sayar, M., de la Cruz, M. O., & Stupp, S. I. Polar Order in Nanostructured Organic Materials. Europhys. Lett. 61, 334–340 (2003). [18] Sayar, M. & Stupp, S. I. Self-organization of rod-coil molecules into nanoaggregates: A coarse grained model. Macromolecules 34, 7135–7139 (2001). [19] Sayar, M., Solis, F. J., de la Cruz, M. O., & Stupp, S. I. Competing interactions among supramolecular structures on surfaces. Macromolecules 33, 7226–7228 (2000). [20] Stupp, S. I., et al. Self-assembly of organic nano-objects into functional materials. MRS Bull. 25, 42–48 (2000). [21] Alparslan, A. K., Sayar, M., & Atilgan, A. R. State-space prediction model for chaotic time series. Phys. Rev. E 58, 2640–2643 (1998). [22] Demirel, M. C., Sayar, M., & Atilgan, A. R. Statistical mechanics of Fermi-Pasta-Ulam chains with the canonical ensemble. Phys. Rev. E 55, 3727–3730 (1997). [23] Sayar, M., Demirel, M. C., & Atilgan, A. R. Dynamics of disordered structures: Effect of non-linearity on the localization. J. Sound Vibr. 205, 372–379 (1997). Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 5/8 Invited Talks Mar. 2004 Title: “Polyelectrolyte Bundles: Finite size at thermodynamic equilibrium?”, Host: Prof. Monica Olvera de la Cruz, Materials Science Dept. , Northwestern University Mar. 2004 Title: “Polyelectrolyte Bundles”, Host: Prof. Canan Atılgan, Sabanci University, Istanbul, Turkey Dec. 2004 Title: “Self Organization of Organic Molecules into Nanostructured Materials”, Host: Irsadi Aksun, Koc University College of Engineering, Istanbul, Turkey Sep. 2006 Title: “Aggregation of Polyelectrolyte Chains into Finite Size Aggregates”, Host: Gerhard Wegner, MPIP, Mainz/Germany Nov. 2010 Title: “Structure and Thermodynamics of Biopolymers”, Host: Prof. Monica Olvera de la Cruz, Northwestern University Feb. 2011 Title: “Biopolymers as Building Blocks for Novel Materials”, Prof. Tülay Tulun, ITU, Istanbul Feb. 2012 Title: “Peptide Based Materials: Assembly, Structure and Thermodynamic Properties”, Host: Dr. Christian Holm, University of Stuttgart Mar. 2012 Title: “Biopolimerler & Kendiliğinden Organizasyon: Oyunun Kurallarn Öğrenmek”, Genç Kimyacılar Derneği, Istanbul Jun. 2013 Adsorption and Assembly of Peptides at a Hydrophobic/Hydrophilic Interface: Environment driven conformational change, Host: Dr. Christine Peter, MaxPlanck Institute for Polymer Research, Mainz, Germany Sep. 2013 Title: “Adsorption and Assembly of Peptides at the Hydrophobic/Hydrophilic Interface: Environment driven conformational change”, Host: Dr. Mustafa Güler, UNAM, Bilkent, Ankara Dec. 2013 Title: “Adsorption and Assembly of Peptides at the Hydrophobic/Hydrophilic Interface: Environment driven conformational change”, Department of Chemistry, Boğaziçi University Conferences Nov. 2004 Polyelectrolyte Bundles: Finite size at thermodynamic equilibrium?, Mehmet Sayar, Juelich Soft Matter Days, Kerkrade, NL Mar. 2005 Polyelectrolyte Bundles: Finite size at thermodynamic equilibrium?, Mehmet Sayar, Hans J. Limbach, Christian Holm, American Physical Society March Meeting, Los Angeles, USA Apr. 2005 Polyelectrolyte Bundles: Finite size at thermodynamic equilibrium?, Mehmet Sayar, Christian Holm, WE Heraus Seminar, Bad Honnef, Netherlands May. 2005 Finite Size Polyelectrolyte Bundles at Thermodynamic Equilibrium, Mehmet Sayar, Christian Holm, Gordon Conference, Il Ciocco, Italy Oct. 2006 Model Polyelectrolyte Systems with Hierarchical Self Asembly: Importance of Counterion Valency, Mehmet Sayar, Berk Hess, Christian Holm, Active Biomimetic Materials, Badhonnef/Germany Jul. 2006 Polyelectrolyte Bundles, Mehmet Sayar, İstanbul İstatistik Fizik Günleri, Istanbul, Turkey May. 2007 Aggregation of Like Charged Polyelectrolytes, Mehmet Sayar, Christian Holm, GRC Conference on Chemistry of Supramolecules & Assemblies, Il Ciocco, Italy Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 6/8 Jun. 2008 Understanding Bubble Formation and Dynamics in DNA, M. Sayar, B. Avsaroglu, A. Kabakcioglu, Polyelectrolytes 2008, Coimbra, Portugal Mar. 2009 Supercoil Formation During DNA Melting, Mehmet Sayar, Barış Avşaroğlu, Alkan Kabakçıoğlu, American Physical Society March 2009 Meeting, Pittsburgh, USA Sep. 2010 Twist writhe partitioning in a coarse grained DNA minicircle model, Sayar, M. and Bavsaroglu, B. and Kabakcioglu, A., Novel Simulation Approaches to Soft Matter Systems, Dresden, Germany Jun. 2010 Driving Force for Adsorption of Amphiphilic Peptides to Air/Water Interface, Engin O., Villa A., Hess B. and Sayar M., Multiscale Molecular Modelling 2010, Edinburgh, UK Mar. 2011 Twist/Writhe Partitioning in DNA Minicircles , Mehmet Sayar & Alkan Kabakcioglu, Biophysical Society, Baltimore, USA Jun. 2011 Self Assembly of Amphiphilic Peptides into One dimensional Objects , Özge Engin, Beytullah Özgür and Mehmet Sayar, NanoTr, Istanbul, Turkey Mar. 2012 Understanding Formation and Structure of Peptide Nanofivers via Steered MD Simulations, Ozge Engin, Beytullah Ozgur, Mehmet Sayar, Biophysical Society, Sandiego, USA Jun. 2012 One Coarse Grained DNA Model for all: From Single Strand to Double Helix, Murat Ozturk, Alkan Kabakcioglu, Mehmet Sayar, Istatistik Fizik Günleri, İstanbul, Turkey Jun. 2012 Fiber Formation via Multi Domain Peptides: Effect of Aliphatic to Aromatic Residue Substitution, Beytullah Ozgur, Ozge Engin, Mehmet Sayar, Istatistik Fizik Günleri, İstanbul, Turkey Jun. 2012 Self assembly at the Interface: Conformational Transition in Peptides , Cahit Dalgicdir & Mehmet Sayar, İstatistik Fizik Günleri, İstanbul, Turkey Jun. 2012 Self assembly at the Interface: Conformational Transition in Peptides , Cahit Dalgicdir & Mehmet Sayar, NanoTR VIII, Ankara, Turkey Jun. 2012 One Coarse Grained DNA Model for all: From Single Strand to Double Helix , Murat Özturk, Alkan Kabakçıoğlu & Mehmet Sayar, NanoTR VIII, Ankara, Turkey Oct. 2012 Biopolymers as Building Blocks for Novel Materials: Computational Modeling of Self assembling materials, Mehmet Sayar, 10th Chemical Physics Congress, Ankara, Turkey Nov. 2012 Self Assembly of Biomolecules at the air/water interface, Mehmet Sayar, MACAN Workshop, Sabanci University, İstanbul, Turkey Mar. 2013 Self Assembly of Peptides at the Air/Water Interface, Mehmet Sayar, American Physical Society March Meeting, 3 , 2013, Baltimore, USA (2012) Sep. 2013 Adsorption, Folding, and Packing of an Amphiphilic Peptide at the Air/Water Interface, Ozge Sensoy and Mehmet Sayar, Workshop on ’Protein Dynamics: From Water Hydration to Crowding Effects’, Freiburg, Germany Sep. 2013 Self assembly of an Amphiphilic Peptide: A Multi Scale Approach, Beytullah Ozgur, Ozge Sensoy, and Mehmet Sayar, Workshop on ’Protein Dynamics: From Water Hydration to Crowding Effects’, Freiburg, Germany Sep. 2013 Ozge Sensoy, and Mehmet Sayar, Workshop on ’Protein Dynamics: From Water Hydration to Crowding Effects’, Freiburg, Germany Nov. 2013 Peptit Bazlı Moleküllerin Hidrofobik/Hidrofilik Arayüzeylerde Davnanışı: Çevresel Etkiler Altında Konformasyon Değişimleri, Mehmet Sayar, TÜBA GEBİP Konya Meeting, Konya, Turkey Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 7/8 Nov. 2014 Peptit Moleküllerinin Makroskopik ve Moleküler Arayüzeylerde Katlanması , Mehmet Sayar, TÜBA GEBİP Afyon Meeting, Afyon, Turkey Teaching Activities MECH 202 Engineering Materials MECH 407 Finite Element Analysis /MECH 507 MECH 590 Seminar in Mechanical Engineering CHBI 438 Intermolecular and Surface Forces /MASE 538 CHBI 405 Polymer Engineering /MECH 423 /CHBI 505 ENGR ENGR MATH MATH CMSE 200 201 203 201 501 Probability and Statistical Methods for Engineers Statistics for Engineers Multivariable Calculus Statistics Introduction to Computational Science and Engineering Conference and Workshop Organization Jun. 2008 ITAP Conference on Bioinformatics and statistical physics of biopolymers, Organizers: Alkan Kabakçıoğlu, Mehmet Sayar, Tuğrul Hakioğlu, Marmaris, Turkey Sep. 2009 Theory and Simulation of Organic and Biological Systems, Organizers: Kurt Kremer, Denis Andrienko, Mehmet Sayar, KU, Istanbul Jan. 2012 A Short Course on Computational Methods for Life-Sciences and Nano-technology, Organizers: Seda Keskin, Mehmet Sayar, KU, Istanbul University Service 2006-2007 2005-2008 2010-2012 2010-2014 2014-to date Editor for Kule Journal Mechanical Engineering Graduate Coordinator Materials Science and Engineering Graduate Coordinator Freshman Advisor CHBI Summer Training Coordinator Koç University, Sarıyer, 34450 İstanbul – Turkey H +90 (212) 3381840 • B [email protected] Í home.ku.edu.tr/∼msayar 8/8